Prof Dame Lesley Fallowfield

Lesley Fallowfield trained at Guy's Hospital London as a nurse before completing a degree in Experimental Psychology. Research for her DPhil in Psychophysics was done at the Universities of Sussex and Cambridge. Her primary research interests include:

Professor Fallowfield has contributed numerous articles to medical journals and has written three textbooks on QoL and communication in health care.

  • BRCA Direct 2

    Following on from the successful BRCA DIRECT trial, NHS England has provided funding to implement the BRCA DIRECT digital pathway in 10-20 centres in England over an 18 month period.


    Examines whether a short (8 min) film about Gene Expression Profiling (GEP) tests used in breast cancer (Oncotype DX® or Prosigna) helps improve patients‘ knowledge.


    A phase III trial of surgery versus active monitoring for Low Risk DCIS (LORIS), incorporating a two year feasibility study. The aim of the main trial is to determine whether women with newly diagnosed low risk DCIS can safely avoid surgery, without detriment to their psychological well-being and can those patients who do require surgery be identified by pathological and radiological criteria.

  • TARGET2 Evaluation

    Evaluation of a new series of TARGET workshops commisioned by Exact Sciences.

  • Trusting Workshops 2024 Evaluation

    Evaluation of the TRUSTING workshops run in spring 2024

  • Burstein H, DeMichele A, Fallowfield L, Somerfield M, & Henry NL. (2024). Endocrine and Targeted Therapy for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2 - Negative Metastatic Breast Cancer - Capivasertib-Fulvestrant: ASCO Rapid Recommendation Update. Journal of Clinical Oncology; Volume 42: 1450-1455 Find it online here 02/04/2024
  • Dilley J, Gentry-Maharaj A, Ryan A, Burnell M, Manchanda R, Kalsi J, ... & Menon U. (2023). Ovarian cancer symptoms in pre-clinical invasive epithelial ovarian cancer-An exploratory analysis nested within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Gynecologic Oncology; 179: 123-130. Find it online here 18/11/2023
  • Macbeth F, Fallowfield L, Treasure E, Ahmad I, Zheng Y, & Treasure T. (2023). Removal or ablation of asymptomatic lung metastases should be reconsidered. BMJ; 383. Find it online here 09/11/2023
  • Wheelwright S, Matthews L, Jenkins V, May S, Rea D, Fairbrother P, Gaunt C, Young J, Pirrie S, Wallis M G, Fallowfield L, on behalf of the LORIS Trial Management Group (2023). Recruiting women with ductal carcinoma in situ to a randomised controlled trial: lessons from the LORIS study. Trials; 24(1): 670. Find it online here 14/10/2023
  • Menon U, Gentry-Maharaj A, Burnell M, Ryan A, Singh N, Manchanda R, ... & Parmar M K. (2023). Tumour stage, treatment, and survival of women with high-grade serous tubo-ovarian cancer in UKCTOCS: an exploratory analysis of a randomised controlled trial. The Lancet Oncology; 24(9): 1018-1028. Find it online here 29/08/2023
  • Menon Usha, Gentry-Maharaj Aleksandra, Burnell Matthew, Apostolidou Sophia, Ryan Andy, Kalsi Jatinderpal K., Singh Naveena, Fallowfield Lesley, "", UKCTOCS team. (2023). Insights from UKCTOCS for design, conduct and analyses of large randomised controlled trials. Health Technology Assessment: 1-38 Find it online here 23/08/2023
  • Fallowfield L, Starkings R, Palmieri C, Tait, A, Stephen L, May S, ... & Jenkins V. (2023). Living with metastatic breast cancer (LIMBER): experiences, quality of life, gaps in information, care and support of patients in the UK. Supportive Care in Cancer; 31(8): 459. Find it online here 11/07/2023
  • Menon U, Gentry-Maharaj A, Burnell M, Ryan A, Kalsi J K, Singh N, ... & Jacobs I J. (2023). Mortality impact, risks, and benefits of general population screening for ovarian cancer: the UKCTOCS randomised controlled trial. Health Technology Assessment; 11: 1-81. Find it online here 31/05/2023
  • Torr B, Jones C, Choi S, Allen S, Kavanaugh G, Hamill M, ... & Turnbull C. (2022). A digital pathway for genetic testing in UK NHS patients with cancer: BRCA-DIRECT randomised study internal pilot. Journal of Medical Genetics; 59(12): 1179-1188. Find it online here 22/07/2022
  • Fallowfield L, Solis-Trapala I, Starkings R, May S, Matthews L, Eccles D, ... & Jenkins V. (2022). Talking about Risk, UncertaintieS of Testing IN Genetics (TRUSTING): development and evaluation of an educational programme for healthcare professionals about BRCA1 & BRCA2 testing. British Journal of Cancer; 127(6): 1116-1122. Find it online here 17/06/2022