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Principal Investigator - Prof Dame Lesley Fallowfield

Co-Investigator - Prof Val Jenkins

Funder: Boehringer Ingelheim GmBH

Funder: Boehringer Ingelheim GmBH

To determine the 'value' of PFS to patients with metastatic cancer:

• 1. Patient understanding of therapeutic intent
• 2. Their goals and priorities
• 3.Trade-offs between burdens/toxicities/QoL and Survival (PFS and OS)
• 4. Patient characteristics that under-pin decisions about treamtment options
• 5. Association of PFS improvement and/or deterioration with QoL and underlying mechanism
• 6. Association of PFS improvement and or deterioration of psychological well-being.

Progression Free Survival (PFS) is commonly used as an endpoint in clinical trials of novel cancer therapies. This study aims to find out what this means for patients. What they understand about and expect from these treatments and if the benefits from the treatment controlling the cancer make it worth any side effects they could or do experience.

• Current Stage:

  Archived

• Publication

  The value of progression-free survival to patients with advanced-stage cancer Find it here

• Publication

  Therapeutic aims of drugs offering only Progression Free Survival are misunderstood by patients, and oncologists may be overly optimistic about likely benefits Find it here

• Publication

  Do drugs offering only PFS maintain quality of life sufficiently from a patient's perspective? Results from AVALPROFS (Assessing the 'VALue' to patients of PROgression Free Survival) study Find it here

• Poster

  Assessing the VALue of PROgression Free Survival (AVALPROFS) Find it here

• Poster

  Assessing the VALue to patients of PROgression Free Survival (AVALPROFS) Quality of Life Results Find it here

• Poster

  Hoping against hope: Are patients' expectations and understanding about therapeutic aims of novel drugs similar to their oncologists? Find it here

• Report

  Further Analyses from AVALPROFS (Trade off questions and Quality of Life) Find it here

EMAIL: adminshore-c@sussex.ac.uk PHONE: 01273 873019 BlueSky: https://bsky.app/profile/shore-c.bsky.social LOCATION: MAP