Principal Investigator: Professor Val Jenkins
Co-Investigator: Professor Dame Lesley Fallowfield
Funded by: Sanofi in association with pH Associates
Prostate cancer is the most common cancer for men in the UK. The main treatment for men with metastatic prostate cancer is hormonal therapy, which slows disease progression and alleviates symptoms. Unfortunately over time most patients will develop resistance to the hormone therapy and the cancer continues to grow. This is known as hormone refractory or castrate resistant prostate cancer (cRPC), which is initially treated with chemotherapy.
In the EXPECT study (expectations and experiences of men with metastatic prostate cancer), we explored the type of information provided to patients and their partners by the health care professionals treating them regarding the benefits and side effects of further treatment. Certain side effects may have far more relevance to the decision-making process for some patients than clinicians are aware, for example what may be termed relatively minor symptoms by the clinician may in fact have a profound effect on certain individuals and strongly influence their decision-making process.
In the EXPECT feasibility study we conducted a systematic review of the type of information required, decision making processes and Quality of Life (QoL) in men with cRPC and their partners.
Publications arising from this research include:
Jenkins V, Fallowfield L. No man’s land: information needs and resources of men with metastatic castrate resistant prostate cancer. Supportive Care in Cancer, 2016, 24(11);4471-4473
Fallowfield L, Payne H, Jenkins V. Patient-reported outcomes in metastatic castration-resistant prostate cancer. Nature Reviews Clinical Oncology, 2016, 13:643-650.
We involved a patient and partner advisory group to explore the unmet needs of this group and also consulted clinicians and specialist nurses for their views to inform the design of an observational, interview based study EXperiences of TREatment and Quality Of Life of men with mCRPC (EXTREQOL) .
Follow this link to read more about EXTREQOL.